Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.

ABSTRACT: Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using spinally intact and chronic transected rats of both sexes in acute urethane-anesthetized terminal preparations, scES was systematically applied using a modified Specify 5-6-5 (Medtronic) electrode during bladder filling/emptying cycles while recording bladder and colorectal pressures and external urethral and anal sphincter electromyography activity. The results indicate frequency-dependent effects on void volume, micturition, bowel peristalsis, and sphincter activity just above visualized movement threshold intensities that differed depending upon neurological intactness, with some sex-dependent differences. Thereafter, a custom-designed

SUBMITTER: Hoey RF 

PROVIDER: S-EPMC7870824 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature