Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry.

ABSTRACT: Breast cancer largely dominates the global cancer burden statistics; however, there are striking disparities in mortality rates across countries. While socioeconomic factors contribute to population-based differences in mortality, they do not fully explain disparity among women of African ancestry (AA) and Arab ancestry (ArA) compared to women of European ancestry (EA). In this study, we sought to identify molecular differences that could provide insight into the biology of ancestry-associated disparities in clinical outcomes. We applied a unique approach that combines the use of curated survival data from The Cancer Genome Atlas (TCGA) Pan-Cancer clinical data resource, improved single-nucleotide polymorphism-based inferred ancestry assignment, and a novel breast cancer subtype classifica

SUBMITTER: Roelands J 

PROVIDER: S-EPMC7870839 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature