Integrated analysis identifies oxidative stress genes associated with progression and prognosis in gastric cancer.

ABSTRACT: Oxidative stress (OS) reactions are reported to be associated with oncogenesis and tumor progression. However, little is known about the potential diagnostic value of OS in gastric cancer (GC). This study identified hub OS genes associated with the prognosis and progression of GC and illustrated the underlying mechanisms. The transcriptome data and corresponding GC clinical information were collected from The Cancer Genome Atlas (TCGA) database. Aberrantly expressed OS genes between tumors and adjacent normal tissues were screened, and 11 prognosis-associated genes were identified with a series of bioinformatic analyses and used to construct a prognostic model. These genes were validated in the Gene Expression Omnibus (GEO) database. Furthermore, weighted gene co-expression network analysi

SUBMITTER: Wu Z 

PROVIDER: S-EPMC7870842 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature