Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia.

ABSTRACT: Increased endogenous hydrogen sulfide (H₂S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H₂S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selective phosphatases. However, the role of CBS and H₂S in chronic myeloid leukemia (CML) remains elusive. In this study, we found that CBS and H₂S levels were increased in the bone marrow mononuclear cells of pediatric CML patients, as well as in the CML-derived K562 cells and CBS expression levels were correlated with different disease phases. Inhibition of CBS reduced the proliferation of the CML primary bone marrow mononuclear cells and induced growth inhibition, apoptosis, cell cycle arrest, and migration suppression in K562 cells and tumor

SUBMITTER: Wang D 

PROVIDER: S-EPMC7870845 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature