Mutational processes in cancer preferentially affect binding of particular transcription factors.

ABSTRACT: Protein binding microarrays provide comprehensive information about the DNA binding specificities of transcription factors (TFs), and can be used to quantitatively predict the effects of DNA sequence variation on TF binding. There has also been substantial progress in dissecting the patterns of mutations, i.e., the "mutational signatures", generated by different mutational processes. By combining these two layers of information we can investigate whether certain mutational processes tend to preferentially affect binding of particular classes of TFs. Such preferential alterations of binding might predispose to particular oncogenic pathways. We developed and implemented a method, termed "Signature-QBiC", that integrates protein binding microarray data with the signatures of mutational proces

SUBMITTER: Liu M 

PROVIDER: S-EPMC7870974 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature