Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19.

ABSTRACT:

Introduction

Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential antiviral and anti-inflammatory effects.

Objective

The aim of this study was to examine the association between chlorpromazine use and mortality among adult patients hospitalized for COVID-19.

Methods

We conducted an observational, multicenter, retrospective study at Assistance Publique-Hôpitaux de Paris (AP-HP) Greater Paris University hospitals. Study baseline was defined as the date of first prescription of chlorpromazine during hospitalization for COVID-19. The primary endpoint was death. Among patients who had not been hospitalized in intensive care units (ICUs), we compared this endpoint between those who

SUBMITTER: Hoertel N 

PROVIDER: S-EPMC7871023 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature