Cross-species functional alignment reveals evolutionary hierarchy within the connectome.

ABSTRACT: Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization

SUBMITTER: Xu T 

PROVIDER: S-EPMC7871099 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature