Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

The Management of Myelomeningocele Study (MOMS), a randomized clinical trial of prenatal vs standard postnatal repair for myelomeningocele, found that prenatal repair reduced hydrocephalus and hindbrain herniation and improved motor function in children aged 12 to 30 months. The Management of Myelomeningocele Study Follow-up (MOMS2) was conducted in children at ages 5 to 10 years. The primary (neurocognitive) outcome has already been reported.

Objective

To determine whether MOMS2 participants who had prenatal repair have better physical functioning than those with postnatal repair.

Design, setting, and participants

Participants from MOMS were recruited for participation in the follow-up study, MOMS2, conducted from April 9, 2012, to April 15, 2017. For this

SUBMITTER: Houtrow AJ 

PROVIDER: S-EPMC7871205 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature