Association Between Proton Pump Inhibitor Use and Risk of Asthma in Children.

ABSTRACT:

Importance

The use of proton pump inhibitors (PPIs) in children has increased substantially in recent years, concurrently with emerging concerns that these drugs may increase the risk of asthma. Whether PPI use in the broad pediatric population is associated with increased risk of asthma is not known.

Objective

To investigate the association between PPI use and risk of asthma in children.

Design, setting, and participants

This nationwide cohort study collected registry data in Sweden from January 1, 2007, to December 31, 2016. Children and adolescents 17 years or younger were matched by age and propensity score into 80 870 pairs of those who initiated PPI use and those who did not. Data were analyzed from February 1 to September 1, 2020.

Exposures

Initiation of

SUBMITTER: Wang YH 

PROVIDER: S-EPMC7871209 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature