Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection.

ABSTRACT:

Background

The genomes of HIV-2 and some SIV strains contain the accessory gene vpx, which carries out several functions during infection, including the downregulation of SAMHD1. Vpx is also commonly used in experiments to increase HIV-1 infection efficiency in myeloid cells, particularly in studies that investigate the activation of antiviral pathways. However, the potential effects of Vpx on cellular innate immune signaling is not completely understood. We investigated whether and how Vpx affects ISG responses in monocytic cell lines and MDMs during HIV-1 infection.

Results

HIV-1 infection at excessively high virus doses can induce ISG activation, although at the expense of high levels of cell death. At equal infection levels, the ISG response is potentiated by the presenc

SUBMITTER: Cingoz O 

PROVIDER: S-EPMC7871410 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature