Causal relationships between genetically determined metabolites and human intelligence: a Mendelian randomization study.

ABSTRACT: Intelligence predicts important life and health outcomes, but the biological mechanisms underlying differences in intelligence are not yet understood. The use of genetically determined metabotypes (GDMs) to understand the role of genetic and environmental factors, and their interactions, in human complex traits has been recently proposed. However, this strategy has not been applied to human intelligence. Here we implemented a two-sample Mendelian randomization (MR) analysis using GDMs to assess the causal relationships between genetically determined metabolites and human intelligence. The standard inverse-variance weighted (IVW) method was used for the primary MR analysis and three additional MR methods (MR-Egger, weighted median, and MR-PRESSO) were used for sensitivity analyses. Using 25

SUBMITTER: Yang J 

PROVIDER: S-EPMC7871559 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature