Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice.

ABSTRACT:

Background

Ambient air pollution by particulate matters, including diesel exhaust particles (DEP), is a major cause of cardiovascular and metabolic mortality worldwide. The mechanisms by which DEP cause these adverse outcomes are not completely understood. Because the gut microbiota controls cardiovascular and metabolic health, we hypothesized that the fraction of inhaled DEP which reach the gut after mucociliary clearance and swallowing might induce gut dysbiosis and, in turn, contribute to aggravate or induce cardiovascular and metabolic diseases.

Results

Female ApoE^-/- mice fed a Western diet, and wild-type (C57Bl/6) mice fed standard diet were gavaged with DEP (SRM2975) doses corresponding to mucociliary clearance from inhalation exposure (200 or 1000 ng/day,

SUBMITTER: van den Brule S 

PROVIDER: S-EPMC7871568 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature