Effect of prior cancer on survival of hepatocellular carcinoma: implications for clinical trial eligibility criteria.

ABSTRACT:

Background

Patients with cancer history are usually excluded from hepatocellular carcinoma (HCC) clinical trials. However, whether previous malignancy affects the oncological outcomes of HCC patients has not been fully assessed. This study aimed to evaluate whether prior cancer compromised the survival of HCC patients.

Methods

Patients with HCC were extracted from the Surveillance, Epidemiology, and End Results database between 2004 and 2015, and then they were classified into groups with and without prior cancer. The Kaplan-Meier and multivariate Cox regression analysis were adopted to evaluate whether prior cancer impacted clinical outcomes after propensity score matching (PSM) adjusting baseline differences. Validation was performed in the cohort from our institution.

SUBMITTER: Sun X 

PROVIDER: S-EPMC7871582 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature