The production of excretory-secretory molecules from Heligmosomoides polygyrus bakeri fourth stage larvae varies between mixed and single sex cultures.

ABSTRACT:

Background

Excretory-secretory (ES) products are crucial in maintaining helminths in the host. Consequently, the proteins of ES are potential vaccine molecules and potential therapeutic agents for autoimmune diseases. Heligmosomoides polygyrus bakeri, a gastrointestinal parasite of mice, is a model of hookworm infection in humans. ES produced by both sexes of H. polygyrus bakeri L4 stage cultured separately shows different immunomodulatory properties than ES obtained when both sexes are cultured together. Accordingly, the objective of this study was to identify and compare the excretory-secretory molecules from single-sex and mixed cultures.

Methods

The composition of ES of male and female L4 stage nematodes in the presence (cultured together) or absence (cultured alone) of

SUBMITTER: Maruszewska-Cheruiyot M 

PROVIDER: S-EPMC7871589 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature