Identification of monocyte-associated genes as predictive biomarkers of heart failure after acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) is a major contributor of heart failure (HF). Peripheral blood mononuclear cells (PBMCs), mainly monocytes, are the essential initiators of AMI-induced HF. The powerful biomarkers for early identification of AMI patients at risk of HF remain elusive. We aimed to identify monocyte-related critical genes as predictive biomarkers for post-AMI HF.

Methods

We performed weighted gene co-expression network analysis (WGCNA) on transcriptomics of PBMCs from AMI patients who developed HF or did not. Functional enrichment analysis of genes in significant modules was performed via Metascape. Then we obtained the single-cell RNA-sequencing data of recruited monocytes/macrophages from AMI and control mice using the Scanpy and screened 381 diffe

SUBMITTER: Chen Q 

PROVIDER: S-EPMC7871627 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature