Kir6.2, the Pore-Forming Subunit of ATP-Sensitive K⁺ Channels, Is Overexpressed in Human Posttraumatic Brain Contusions.

ABSTRACT: Brain contusions (BCs) are one of the most frequent lesions in patients with moderate and severe traumatic brain injury (TBI). BCs increase their volume due to peri-lesional edema formation and/or hemorrhagic transformation. This may have deleterious consequences and its mechanisms are still poorly understood. We previously identified de novo upregulation sulfonylurea receptor (SUR) 1, the regulatory subunit of adenosine triphosphate (ATP)-sensitive potassium (K_ATP) channels and other channels, in human BCs. Our aim here was to study the expression of the pore-forming subunit of K_ATP, Kir6.2, in human BCs, and identify its localization in different cell types. Protein levels of Kir6.2 were detected by western blot (WB) from 33 contusion specimens obtained from

SUBMITTER: Castro L 

PROVIDER: S-EPMC7872003 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature