Incidence and real-world burden of brain metastases from solid tumors and hematologic malignancies in Ontario: a population-based study.

ABSTRACT:

Background

Although intracranial metastatic disease (IMD) is a frequent complication of cancer, most cancer registries do not capture these cases. Consequently, a data-gap exists, which thwarts system-level quality improvement efforts. The purpose of this investigation was to determine the real-world burden of IMD.

Methods

Patients diagnosed with a non-CNS cancer between 2010 and 2018 were identified from the Ontario Cancer Registry. IMD was identified by scanning hospital administrative databases for cranial irradiation or coding for a secondary brain malignancy (ICD-10 code C793).

Results

25,478 of 601,678 (4.2%) patients with a diagnosis of primary cancer were found to have IMD. The median time from primary cancer diagnosis to IMD was 5.2 (0.7, 15.4) months and var

SUBMITTER: Habbous S 

PROVIDER: S-EPMC7872008 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature