The rectal mucosal but not fecal microbiota detects subclinical ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC), a subtype of inflammatory bowel disease, is characterized by repetitive remission and relapse. Gut microbiome is critically involved in pathogenesis of UC. The shifts in microbiome profile during disease remission remain under-investigated. Recent studies revealed that UC pathogenesis is likely to originate in the mucosal barrier. Therefore, we investigated the effectiveness of mucosal tissue microbiomes to differentiate patients with subclinical UC from healthy individuals. The microbiomes of cecal and rectal biopsies and feces were characterized from 13 healthy individuals and 45 patients with subclinical UC. Total genomic DNA was extracted from the samples, and their microbial communities determined using next-generation sequencing. We found that changes in rela

SUBMITTER: Lin YF 

PROVIDER: S-EPMC7872041 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature