Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.

ABSTRACT: The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with

SUBMITTER: de Jonge K 

PROVIDER: S-EPMC7872097 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature