Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.

ABSTRACT: Sphingolipids are a vital component of plant cellular endomembranes and carry out multiple functional and regulatory roles. Different sphingolipid species confer rigidity to the membrane structure, facilitate trafficking of secretory proteins, and initiate programmed cell death. Although the regulation of the sphingolipid pathway is yet to be uncovered, increasing evidence has pointed to orosomucoid proteins (ORMs) playing a major regulatory role and potentially interacting with a number of components in the pathway, including both enzymes and sphingolipids. However, experimental exploration of new regulatory interactions is time consuming and often infeasible. In this work, a computational approach was taken to address this challenge. A metabolic network of the sphingolipid pathway in pla

SUBMITTER: Alsiyabi A 

PROVIDER: S-EPMC7872301 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature