Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg-Calve-Perthes Disease and Correlation With IL-6.

ABSTRACT: Legg-Calvé-Perthes disease (LCPD) is a childhood ischemic osteonecrosis (ON) of the femoral head associated with the elevation of proinflammatory cytokine interleukin-6 (IL-6) in the synovial fluid. Currently, there is no effective medical therapy for patients with LCPD. In animal models of ischemic ON, articular chondrocytes produce IL-6 in response to ischemic ON induction and IL-6 receptor blockade improves bone healing. High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern released from dying cells. In addition, extracellular HMGB1 protein is a well-known proinflammatory cytokine elevated in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. The purpose of this study was to investigate IL-6-related proinflammatory cytokines, including HMGB

SUBMITTER: Kamiya N 

PROVIDER: S-EPMC7872337 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature