Influence of Prednisolone and Alendronate on the de novo Mineralization of Zebrafish Caudal Fin.

ABSTRACT: Dysregulated balance between bone resorption and formation mediates the onset and progression of osteoporosis. The administration of prednisolone is known to induce osteoporosis, whereas alendronate is commonly used to reverse the process. However, the assessment of the effects of such medicines on the nanostructure of bone remodeling and mechanical properties remains a major technical challenge. The aim of this study was to apply various analytical approaches to evaluate the compositional, morphological, and mechanical properties of regenerative zebrafish caudal fin bony rays affected by prednisolone and alendronate. Adult wild-type AB strain zebrafish were first exposed to 125μM of prednisolone for 14 days to develop glucocorticoid-induced osteoporosis. Fish fins were then amputated and

SUBMITTER: Bohns FR 

PROVIDER: S-EPMC7872341 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature