A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases.

ABSTRACT: The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. Here, we provide shotgun data for whole genome and whole metagenome from a Chinese cohort, identifying no <20% genetic contribution to the gut microbiota. Using common variants-, rare variants-, and copy number variations-based association analyses, we identified abundant signals associated with the gut microbiome especially in metabolic, neurological, and immunological functions. The controversial concept of enterotypes may have a genetic attribute, with the top two loci explaining 11% of the Prevotella-Bacteroides variances. Stratification according to gender led to the identificati

SUBMITTER: Liu X 

PROVIDER: S-EPMC7873036 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature