Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.

ABSTRACT: Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P = 7.50 × 10^-3) and show that Qataris of Arab descent have significantly lower

SUBMITTER: Rossi N 

PROVIDER: S-EPMC7873199 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature