Voluntary intake of psychoactive substances is regulated by the dopamine receptor Dop1R1 in Drosophila.

ABSTRACT: Dysregulated motivation to consume psychoactive substances leads to addictive behaviors that often result in serious health consequences. Understanding the neuronal mechanisms that drive drug consumption is crucial for developing new therapeutic strategies. The fruit fly Drosophila melanogaster offers a unique opportunity to approach this problem with a battery of sophisticated neurogenetic tools available, but how they consume these drugs remains largely unknown. Here, we examined drug self-administration behavior of Drosophila and the underlying neuronal mechanisms. We measured the preference of flies for five different psychoactive substances using a two-choice feeding assay and monitored its long-term changes. We found that flies show acute preference for ethanol and methamphetamine, b

SUBMITTER: Kanno M 

PROVIDER: S-EPMC7873259 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature