Genetic predictors of participation in optional components of UK Biobank.

ABSTRACT: Large studies such as UK Biobank are increasingly used for GWAS and Mendelian randomization (MR) studies. However, selection into and dropout from studies may bias genetic and phenotypic associations. We examine genetic factors affecting participation in four optional components in up to 451,306 UK Biobank participants. We used GWAS to identify genetic variants associated with participation, MR to estimate effects of phenotypes on participation, and genetic correlations to compare participation bias across different studies. 32 variants were associated with participation in one of the optional components (P < 6 × 10^-9), including loci with links to intelligence and Alzheimer's disease. Genetic correlations demonstrated that participation bias was common across studies. MR showed

SUBMITTER: Tyrrell J 

PROVIDER: S-EPMC7873270 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature