Estimation of three-dimensional chromatin morphology for nuclear classification and characterisation.

ABSTRACT: Classification and characterisation of cellular morphological states are vital for understanding cell differentiation, development, proliferation and diverse pathological conditions. As the onset of morphological changes transpires following genetic alterations in the chromatin configuration inside the nucleus, the nuclear texture as one of the low-level properties if detected and quantified accurately has the potential to provide insights on nuclear organisation and enable early diagnosis and prognosis. This study presents a three dimensional (3D) nuclear texture description method for cell nucleus classification and variation measurement in chromatin patterns on the transition to another phenotypic state. The proposed approach includes third plane information using hyperplanes into the d

SUBMITTER: Rana P 

PROVIDER: S-EPMC7873284 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature