Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice.

ABSTRACT:

Objective

Maintenance of glucose homeostasis requires the precise regulation of hormone secretion from the endocrine pancreas. Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor whose activation in islets of Langerhans promotes insulin and glucagon secretion and inhibits somatostatin secretion. However, the contribution of individual islet cell types (α, β, and δ cells) to the insulinotropic and glucagonotropic effects of GPR120 remains unclear. As gpr120 mRNA is enriched in somatostatin-secreting δ cells, we hypothesized that GPR120 activation stimulates insulin and glucagon secretion via inhibition of somatostatin release.

Methods

Glucose tolerance tests were performed in mice after administration of selective GPR120 agonist Compound A. Insulin, gluc

SUBMITTER: Croze ML 

PROVIDER: S-EPMC7873385 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature