SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.

ABSTRACT:

Objective

The intestinal epithelium is a rapidly renewing tissue which plays central roles in nutrient uptake, barrier function and the prevention of intestinal inflammation. Control of epithelial differentiation is essential to these processes and is dependent on cell type-specific activity of transcription factors which bind to accessible chromatin. Here, we studied the role of SET Domain Bifurcated Histone Lysine Methyltransferase 1, also known as ESET (SETDB1), a histone H3K9 methyltransferase, in intestinal epithelial homeostasis and IBD.

Design

We investigated mice with constitutive and inducible intestinal epithelial deletion of Setdb1, studied the expression of SETDB1 in patients with IBD and mouse models of IBD, and investigated the abundance of SETDB1

SUBMITTER: Juznic L 

PROVIDER: S-EPMC7873423 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature