Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors.

ABSTRACT: In recent years, cancer immunotherapy experienced remarkable developments and it is nowadays considered a promising therapeutic frontier against many types of cancer, especially hematological malignancies. However, in most types of solid tumors, immunotherapy efficacy is modest, partly because of the limited accessibility of lymphocytes to the tumor core. This immune exclusion is mediated by a variety of physical, functional and dynamic barriers, which play a role in shaping the immune infiltrate in the tumor microenvironment. At present there is no unified and integrated understanding about the role played by different postulated models of immune exclusion in human solid tumors. Systematically mapping immune landscapes or "topographies" in cancers of different histology is of pivotal impo

SUBMITTER: Pietrobon V 

PROVIDER: S-EPMC7873485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature