Activin A impairs ActRIIA⁺ neutrophil recruitment into infected skin of mice.

ABSTRACT: Activin A levels are elevated during multiple severe infections and associated with an increased risk of death. However, the role of activin A in bacterial infection is still unclear. Here, we found that activin A levels were increased during S. aureus skin infection in mice. Administration of activin A increased the bacterial burden and promoted the spread of bacteria in vivo. Moreover, activin A inhibited neutrophil chemotaxis to N-formylmethionine-leucyl-phenylalanine via the type IIA activin receptor (ActRIIA) in vitro and impaired ActRIIA⁺ neutrophil recruitment to infection foci in vivo. Additionally, we identified a novel subpopulation of neutrophils, ActRIIA⁺ neutrophils, which exhibit superior phagocytic capacity compared to ActRII

SUBMITTER: Qi Y 

PROVIDER: S-EPMC7873648 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature