Biliary Microbial Structure of Gallstone Patients With a History of Endoscopic Sphincterotomy Surgery.

ABSTRACT: The biliary microbiota is related to the pathogenesis of human bile duct stones. However, the extent to which a history of invasive endoscopic sphincterotomy (EST) affects the biliary bacterial community remains largely unknown. We collected bile samples from the common bile duct of 100 choledocholithiasis patients. We performed 16S rRNA sequencing to investigate and compare the biliary microbial community. The patients without antibiotic treatment (AT) were grouped into three clusters based on their biliary microbial compositions. The patients with a history of EST were significantly enriched in one cluster mainly consisting of gastrointestinal bacteria compared with the other two clusters consisting of oral and environmental bacteria. The β-diversities of patients with and without EST we

SUBMITTER: Shen H 

PROVIDER: S-EPMC7873689 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature