Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia.

ABSTRACT: Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset gestational hypertension with (or without) proteinuria or end-organ failure, exclusively observed in humans. It is a leading cause of maternal morbidity affecting 3-7% of pregnant women worldwide. PE pathophysiology could result from abnormal placentation due to a defective trophoblastic invasion and an impaired remodeling of uterine spiral arteries, leading to a poor adaptation of utero-placental circulation. This would be associated with hypoxia/reoxygenation phenomena, oxygen gradient fluctuations, altered antioxidant capacity, oxidative stress, and reduced nitric oxide (NO) bioavailability. This results in part from the reaction of NO with the radical anion superoxide (O₂^•-), which

SUBMITTER: Guerby P 

PROVIDER: S-EPMC7873691 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature