Association between antihypertensive treatment and adverse events: systematic review and meta-analysis.

ABSTRACT:

Objective

To examine the association between antihypertensive treatment and specific adverse events.

Design

Systematic review and meta-analysis.

Eligibility criteria

Randomised controlled trials of adults receiving antihypertensives compared with placebo or no treatment, more antihypertensive drugs compared with fewer antihypertensive drugs, or higher blood pressure targets compared with lower targets. To avoid small early phase trials, studies were required to have at least 650 patient years of follow-up.

Information sources

Searches were conducted in Embase, Medline, CENTRAL, and the Science Citation Index databases from inception until 14 April 2020.

Main outcome measures

The primary outcome was falls during trial follow-up. Secondary outcomes were ac

SUBMITTER: Albasri A 

PROVIDER: S-EPMC7873715 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature