Association between use of macrolides in pregnancy and risk of major birth defects: nationwide, register based cohort study.

ABSTRACT:

Objective

To examine the association between the use of macrolide antibiotics in pregnancy and the risk of major birth defects.

Design

Nationwide, register based cohort study.

Setting

Denmark, 1997-2016.

Participants

Of 1 192 539 live birth pregnancies, pregnancies during which macrolides had been used (13 019) were compared with those during which penicillin (that is, phenoxymethylpenicillin) had been used (matched in a 1:1 ratio on propensity scores). Other comparative groups were pregnancies when macrolides had been used recently but before pregnancy (matched 1:1) and pregnancies where no antibiotics had been used (matched 1:4).

Main outcome measures

Association with an outcome of any major birth defect and specific subgroups of birth defects were ass

SUBMITTER: Andersson NW 

PROVIDER: S-EPMC7873722 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature