Immunogenicity and Safety of Reduced-Dose Intradermal vs Intramuscular Influenza Vaccines: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Low-dose intradermal influenza vaccines could be a suitable alternative to full intramuscular dose during vaccine shortages.

Objective

To compare the immunogenicity and safety of the influenza vaccine at reduced or full intradermal doses with full intramuscular doses to inform policy design in the event of vaccine shortages.

Data sources

MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for studies published from 2010 until June 5, 2020.

Study selection

All comparative studies across all ages assessing the immunogenicity or safety of intradermal and intramuscular influenza vaccinations were included.

Data extraction and synthesis

Data were extracted by a single reviewer and verified by a second reviewer. Dis

SUBMITTER: Egunsola O 

PROVIDER: S-EPMC7873776 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature