Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial.

ABSTRACT:

Importance

The optimal transfusion strategy in patients with acute myocardial infarction and anemia is unclear.

Objective

To determine whether a restrictive transfusion strategy would be clinically noninferior to a liberal strategy.

Design, setting, and participants

Open-label, noninferiority, randomized trial conducted in 35 hospitals in France and Spain including 668 patients with myocardial infarction and hemoglobin level between 7 and 10 g/dL. Enrollment could be considered at any time during the index admission for myocardial infarction. The first participant was enrolled in March 2016 and the last was enrolled in September 2019. The final 30-day follow-up was accrued in November 2019.

Interventions

Patients were randomly assigned to undergo a restrictive

SUBMITTER: Ducrocq G 

PROVIDER: S-EPMC7873781 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature