Dialysis Initiation and All-Cause Mortality Among Incident Adult Patients With Advanced CKD: A Meta-analysis With Bias Analysis.

ABSTRACT:

Rationale & objectives

Due to unmeasured confounding, observational studies have limitations when assessing whether dialysis initiation reduces mortality compared with conservative therapy among adults with advanced chronic kidney disease (CKD). We addressed this issue in this meta-analysis.

Study design

Meta-analysis with bias analysis for unmeasured confounding.

Setting & study population

Adults with stage 4 or 5 CKD who had initiated dialysis or conservative treatment.

Selection criteria for studies

Prospective or retrospective cohort studies comparing survival of dialysis versus conservatively managed patients were searched on MEDLINE and Embase from January 2009 to March 20, 2019.

Data extraction

HRs of all-cause mortality associated with dialysis i

SUBMITTER: Fu R 

PROVIDER: S-EPMC7873831 | biostudies-literature | 2021 Jan-Feb

REPOSITORIES: biostudies-literature