Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer.

ABSTRACT: Wnt signaling is one of the key signaling pathways that govern numerous physiological activities such as growth, differentiation and migration during development and homeostasis. As pathway misregulation has been extensively linked to pathological processes including malignant tumors, a thorough understanding of pathway regulation is essential for development of effective therapeutic approaches. A prominent feature of cancer cells is that they significantly differ from healthy cells with respect to their plasma membrane composition and lipid organization. Here, we review the key role of membrane composition and lipid order in activation of Wnt signaling pathway by tightly regulating formation and interactions of the Wnt-receptor complex. We also discuss in detail how plasma membrane compon

SUBMITTER: Azbazdar Y 

PROVIDER: S-EPMC7873896 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature