From the Basis of Epimorphic Regeneration to Enhanced Regenerative Therapies.

ABSTRACT: Current cell-based therapies to treat degenerative diseases such as osteoarthritis (OA) fail to offer long-term beneficial effects. The therapeutic effects provided by mesenchymal stem cell (MSC) injection, characterized by reduced pain and an improved functional activity in patients with knee OA, are reported at short-term follow-up since the improved outcomes plateau or, even worse, decline several months after MSC administration. This review tackles the limitations of MSC-based therapy for degenerative diseases and highlights the lessons learned from regenerative species to comprehend the coordination of molecular and cellular events critical for complex regeneration processes. We discuss how MSC injection generates a positive cascade of events resulting in a long-lasting systemic immun

SUBMITTER: Laplace-Builhe B 

PROVIDER: S-EPMC7873919 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature