Study on Isomeric Impurities in Cefotiam Hydrochloride.

ABSTRACT: In this study, two isomeric impurities were identified in cefotiam hydrochloride injection preparation and were characterized. Column-switching HPLC-MS and NMR techniques were used to identify the impurity 1 as the Δ3(4) isomers of cefotiam. Using software-based calculations, it was predicted that neither of the isomeric impurities was embryotoxic. This study provides a reference for the production, storage, and quality control of cefotiam and related cephalosporin antibiotics.

SUBMITTER: Tian Y 

PROVIDER: S-EPMC7873999 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature