Identification of Heterogeneous Subtypes of Mild Cognitive Impairment Using Cluster Analyses Based on PET Imaging of Tau and Astrogliosis.

ABSTRACT: Background: Mild cognitive impairment (MCI) is a condition with diverse causes and clinical outcomes that can be categorized into subtypes. [¹⁸F]THK5351 has been known to detect reactive astrogliosis as well as tau which is accompanied by neurodegenerative changes. Here, we identified heterogeneous groups of MCI patients using THK retention patterns and a graph theory approach, allowing for the comparison of risk of progression to dementia in these MCI subgroups. Methods: Ninety-seven participants including 60 MCI patients and individuals with normal cognition (NC, n = 37) were included and undertook 3T MRI, [¹⁸F]THK5351 PET, and detailed neuropsychological tests. [¹⁸F]Flutemetamol PET was also performed in 62 participants. We calculate

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC7874013 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature