Extracting the GEMs: Genotype, Environment, and Microbiome Interactions Shaping Host Phenotypes.

ABSTRACT: One of the fundamental tenets of biology is that the phenotype of an organism (Y) is determined by its genotype (G), the environment (E), and their interaction (GE). Quantitative phenotypes can then be modeled as Y = G + E + GE + e, where e is the biological variance. This simple and tractable model has long served as the basis for studies investigating the heritability of traits and decomposing the variability in fitness. The importance and contribution of microbe interactions to a given host phenotype is largely unclear, nor how this relates to the traditional GE model. Here we address this fundamental question and propose an expansion of the original model, referred to as GEM, which explicitly incorporates the contrib

SUBMITTER: Oyserman BO 

PROVIDER: S-EPMC7874016 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature