Association Between Furosemide Exposure and Clinical Outcomes in a Retrospective Cohort of Critically Ill Children.

ABSTRACT: Furosemide is commonly prescribed in critically ill patients to increase the urine output and prevent fluid overload (FO) and acute kidney injury (AKI), but not supported by conclusive evidence. There remain conflicting findings on whether furosemide associates with AKI and adverse outcomes. Information on the impact of furosemide on adverse outcomes in a general population of pediatric intensive care unit (PICU) is limited. The aim of the cohort study was to investigate the associations of furosemide with AKI and clinical outcomes in critically ill children. Study Design: We retrospectively reviewed a cohort of 456 critically ill children consecutively admitted to PICU from January to December 2016. The exposure of interest was the use of furosemide in the first week after admissio

SUBMITTER: Dai X 

PROVIDER: S-EPMC7874070 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature