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P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3^*Leiden Mice via Systemic Inhibition of Regulatory T Cells.

ABSTRACT: Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of regulatory Tregs. Method: ApoE3^*Leiden (n = 13) and ApoE3^*LeidenxPCAF^-/- (n = 13) were fed a high-fat diet (HFD) containing 1.25% cholesterol. Systemic FoxP3⁺ T cells were measured every 4 weeks by flow cytometry (n = 6). After 5-months of HFD, mice were euthanized, and hearts and blood were collected. IL-6 and TNFα concentrations were measured in plasma to identify systemic

SUBMITTER: de Jong A

PROVIDER: S-EPMC7874080 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Dataset Information

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3^*Leiden Mice via Systemic Inhibition of Regulatory T Cells.

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Dataset Information

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3^*Leiden Mice via Systemic Inhibition of Regulatory T Cells.