Association Between Circulating Linoleic Acid and Risk of Ischemic Stroke.

ABSTRACT:

Background

Observational studies have shown an inverse association between circulating linoleic acid (LA) and risk of ischemic stroke (IS).

Objective

The aim of this study was to explore whether genetic variants predicting levels of circulating LA are associated with IS and its subtypes using a two-sample Mendelian randomization (MR) analysis.

Methods

LA-related single-nucleotide polymorphisms (SNPs) were selected from a genome-wide association study of 8,631 participants, and summary statistics of IS and IS subtypes were obtained from the MEGASTROKE consortium. MR analysis was performed using the inverse-variance weighted (IVW) method complemented with other approaches, including weighted-median, weighted-mode, MR Pleiotropy RESidual Sum and Outlier test and MR-Egger

SUBMITTER: Ye D 

PROVIDER: S-EPMC7874191 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature