Vascular ATP-sensitive K⁺ channels support maximal aerobic capacity and critical speed via convective and diffusive O₂ transport.

ABSTRACT:

Key points

Oral sulphonylureas, widely prescribed for diabetes, inhibit pancreatic ATP-sensitive K⁺ (K_ATP ) channels to increase insulin release. However, K_ATP channels are also located within vascular (endothelium and smooth muscle) and muscle (cardiac and skeletal) tissue. We evaluated left ventricular function at rest, maximal aerobic capacity ( V̇ O₂ max) and submaximal exercise tolerance (i.e. speed-duration relationship) during treadmill running in rats, before and after systemic K_ATP channel inhibition via glibenclamide. Glibenclamide impaired critical speed proportionally more than V̇ O₂ max but did not alter resting cardiac output. Vascular K_ATP channel function (topical glibenclamide superfused o

SUBMITTER: Colburn TD 

PROVIDER: S-EPMC7874302 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature