Olfactomedin 4-Positive Neutrophils Are Upregulated after Hemorrhagic Shock.

ABSTRACT: Neutrophils are vital to both the inflammatory cascade and tissue repair after an injury. Neutrophil heterogeneity is well established but there is less evidence for significant, different functional roles for neutrophil subsets. OLFM4 (Olfactomedin-4) is expressed by a subset of neutrophils, and high expression of OLFM4 is associated with worse outcomes in patients with sepsis and acute respiratory distress syndrome. We hypothesized that an increased number of OLFM4⁺ neutrophils would occur in trauma patients with worse clinical outcomes. To test this, we prospectively enrolled patients who suffered a blunt traumatic injury. Blood was collected at the time of admission, Day 3, and Day 7 and analyzed for the percentage of neutrophils expressing OLFM4. We found that a subs

SUBMITTER: Kassam AF 

PROVIDER: S-EPMC7874390 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature