Assessment of assumptions underlying models of prokaryotic pangenome evolution.

ABSTRACT:

Background

The genomes of bacteria and archaea evolve by extensive loss and gain of genes which, for any group of related prokaryotic genomes, result in the formation of a pangenome with the universal, asymmetrical U-shaped distribution of gene commonality. However, the evolutionary factors that define the specific shape of this distribution are not thoroughly understood.

Results

We investigate the fit of simple models of genome evolution to the empirically observed gene commonality distributions and genome intersections for 33 groups of closely related bacterial genomes. A model with an infinite external gene pool available for gene acquisition and constant genome size (IGP-CGS model), and two gene turnover rates, one for slow- and the other one for fast-evolving genes, all

SUBMITTER: Sela I 

PROVIDER: S-EPMC7874442 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature