Genome-wide transcriptome study using deep RNA sequencing for myocardial infarction and coronary artery calcification.

ABSTRACT:

Background

Coronary artery calcification (CAC) is a noninvasive measure of coronary atherosclerosis, the proximal pathophysiology underlying most cases of myocardial infarction (MI). We sought to identify expression signatures of early MI and subclinical atherosclerosis in the Framingham Heart Study (FHS). In this study, we conducted paired-end RNA sequencing on whole blood collected from 198 FHS participants (55 with a history of early MI, 72 with high CAC without prior MI, and 71 controls free of elevated CAC levels or history of MI). We applied DESeq2 to identify coding-genes and long intergenic noncoding RNAs (lincRNAs) differentially expressed in MI and high CAC, respectively, compared with the control.

Results

On average, 150 million paired-end reads were obtained for

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7874462 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature